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RGS7
inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations. Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity). Interacts with 14-3-3 protein Tau and SNAP25BP. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, RGS |
| Chromosomal Location of Human Ortholog: 1q43|1q23.1 |
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Cellular Component:
cytosol; plasma membrane
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Molecular Function:
G-protein beta-subunit binding; GTPase activator activity; GTPase activity
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Biological Process:
G protein-coupled receptor signaling pathway; intracellular signal transduction; negative regulation of signal transduction; positive regulation of GTPase activity; protein folding
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Reference #:
P49802
(UniProtKB)
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Alt. Names/Synonyms: Regulator of G-protein signaling 7; regulator of G-protein signaling RGS7; regulator of G-protein signalling 7; RGS7
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Gene Symbols: RGS7
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Molecular weight:
57,668 Da
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Basal Isoelectric point:
8.33
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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