RGS7 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations. Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity). Interacts with 14-3-3 protein Tau and SNAP25BP. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Chromosomal Location of Human Ortholog: 1q43|1q23.1
Cellular Component:  cytosol; plasma membrane
Molecular Function:  G-protein beta-subunit binding; GTPase activator activity; GTPase activity
Biological Process:  G protein-coupled receptor signaling pathway; intracellular signal transduction; negative regulation of signal transduction; positive regulation of GTPase activity; protein folding
Reference #:  P49802 (UniProtKB)
Alt. Names/Synonyms: Regulator of G-protein signaling 7; regulator of G-protein signaling RGS7; regulator of G-protein signalling 7; RGS7
Gene Symbols: RGS7
Molecular weight: 57,668 Da
Basal Isoelectric point: 8.33  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene