TOB1 Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay. Belongs to the BTG family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell cycle regulation
Chromosomal Location of human Ortholog: 17q21.33
Cellular Component:  CCR4-NOT complex; cytoplasm; nucleus
Molecular Function:  protein binding; receptor tyrosine kinase binding; SMAD binding; transcription corepressor activity
Biological Process:  negative regulation of BMP signaling pathway; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; negative regulation of osteoblast differentiation; negative regulation of translation; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; regulation of gene expression; regulation of SMAD protein signal transduction
Reference #:  P50616 (UniProtKB)
Alt. Names/Synonyms: APRO5; APRO6; MGC104792; MGC34446; PIG49; proliferation-inducing gene 49; Protein Tob1; TOB; TOB1; Transducer of erbB-2 1; transducer of ERBB2, 1; TROB; TROB1
Gene Symbols: TOB1
Molecular weight: 38,155 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
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TOB1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein