TOB1 Anti-proliferative protein that interacts with the erbB- 2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors. Belongs to the BTG family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell cycle regulation
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component:  CCR4-NOT complex
Molecular Function:  protein binding; receptor tyrosine kinase binding; SH3/SH2 adaptor activity; SMAD binding
Biological Process:  negative regulation of BMP signaling pathway; negative regulation of cell proliferation; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; negative regulation of nucleic acid-templated transcription; negative regulation of osteoblast differentiation; negative regulation of translation; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of signal transduction; regulation of SMAD protein signal transduction
Reference #:  P50616 (UniProtKB)
Alt. Names/Synonyms: APRO6; MGC104792; MGC34446; PIG49; Protein Tob1; TOB; TOB1; Transducer of erbB-2 1; transducer of ERBB2, 1; TROB; TROB1
Gene Symbols: TOB1
Molecular weight: 38,155 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene