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TOB1
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay. Belongs to the BTG family. Ubiquitous. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Cell cycle regulation |
| Chromosomal Location of human Ortholog: 17q21.33 |
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Cellular Component:
CCR4-NOT complex; cytoplasm; nucleus
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Molecular Function:
protein binding; receptor tyrosine kinase binding; SMAD binding; transcription corepressor activity
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Biological Process:
negative regulation of BMP signaling pathway; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; negative regulation of osteoblast differentiation; negative regulation of translation; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; regulation of gene expression; regulation of SMAD protein signal transduction
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Reference #:
P50616
(UniProtKB)
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Alt. Names/Synonyms: APRO5; APRO6; MGC104792; MGC34446; PIG49; proliferation-inducing gene 49; Protein Tob1; TOB; TOB1; Transducer of erbB-2 1; transducer of ERBB2, 1; TROB; TROB1
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Gene Symbols: TOB1
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Molecular weight:
38,155 Da
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Basal Isoelectric point:
6.45
Predict pI for various phosphorylation states
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