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ADCY4
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family |
| Chromosomal Location of Human Ortholog: 15p13 |
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Cellular Component:
cytoplasm; dendrite; integral component of membrane; integral component of plasma membrane; membrane; nucleus; plasma membrane; protein-containing complex
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Molecular Function:
adenylate cyclase activity; ATP binding; G-protein beta/gamma-subunit complex binding; metal ion binding; protein kinase C binding
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; intracellular signal transduction
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Reference #:
P26770
(UniProtKB)
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Alt. Names/Synonyms: Adcy4; adenylate cyclase 4; Adenylate cyclase type 4; Adenylate cyclase type IV; Adenylyl cyclase 4; ATP pyrophosphate-lyase 4; MGC93493
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Gene Symbols: Adcy4
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Molecular weight:
118,799 Da
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Basal Isoelectric point:
8.15
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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NF-kB Signaling
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Parkinson's Disease
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