ADCY4 Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adenylyl cyclase; EC; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of rat Ortholog: 15p13
Cellular Component:  cytoplasm; dendrite; membrane; nucleus; plasma membrane; protein-containing complex
Molecular Function:  adenylate cyclase activity; ATP binding; G-protein beta/gamma-subunit complex binding; metal ion binding; protein kinase C binding
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; intracellular signal transduction
Reference #:  P26770 (UniProtKB)
Alt. Names/Synonyms: Adcy4; adenylate cyclase 4; Adenylate cyclase type 4; Adenylate cyclase type IV; Adenylyl cyclase 4; ATP pyrophosphate-lyase 4; MGC93493
Gene Symbols: Adcy4
Molecular weight: 118,799 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  NF-kB Signaling  |  Parkinson's Disease
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene