ADCY4 Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adenylyl cyclase; EC; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 14q12
Cellular Component:  cytoplasm; dendrite; membrane; plasma membrane
Molecular Function:  adenylate cyclase activity; ATP binding; metal ion binding; protein binding; protein kinase C binding
Biological Process:  activation of adenylate cyclase activity; activation of protein kinase A activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; cellular response to glucagon stimulus; G protein-coupled receptor signaling pathway; renal water homeostasis
Reference #:  Q8NFM4 (UniProtKB)
Alt. Names/Synonyms: AC4; ADCY4; adenylate cyclase 4; Adenylate cyclase type 4; Adenylate cyclase type IV; Adenylyl cyclase 4; ATP pyrophosphate-lyase 4
Gene Symbols: ADCY4
Molecular weight: 119,794 Da
Basal Isoelectric point: 7.31  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  NF-kB Signaling  |  Parkinson's Disease
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein