SKP2 an F-box protein of the SCF (SKP1-CUL1-F- box protein) E3 ubiquitin ligase system. The F-box component of the SCF complex is responsible for recognizing different substrates for ubiquitination. The SCF E3 complex mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5p13.2
Cellular Component:  cytosol; nucleolus; nucleoplasm; nucleus; SCF ubiquitin ligase complex
Molecular Function:  identical protein binding; protein binding
Biological Process:  cellular response to cell-matrix adhesion; defense response to virus; G1/S transition of mitotic cell cycle; innate immune response; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of protein polyubiquitination; positive regulation of smooth muscle cell proliferation; post-translational protein modification; proteasome-mediated ubiquitin-dependent protein catabolic process; protein deubiquitination; protein K48-linked ubiquitination; protein polyubiquitination; regulation of apoptotic process; viral process
Reference #:  Q13309 (UniProtKB)
Alt. Names/Synonyms: CDK2/cyclin A-associated protein p45; cyclin A/CDK2-associated protein p45; Cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; FBL1; FBXL1; FLB1; MGC1366; p45skp2; S-phase kinase-associated protein 2; S-phase kinase-associated protein 2 (p45); SKP2
Gene Symbols: SKP2
Molecular weight: 47,761 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein