SKP2 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration. Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Cell cycle regulation; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of human Ortholog: 5p13.2

Cellular Component: cytosol; nucleolus; nucleoplasm; nucleus; SCF ubiquitin ligase complex

Molecular Function: identical protein binding; protein binding

Biological Process: defense response to virus; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; innate immune response; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of protein polyubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; regulation of apoptotic process; regulation of cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Reference #: Q13309 (UniProtKB)

Alt. Names/Synonyms: CDK2/cyclin A-associated protein p45; cyclin A/CDK2-associated protein p45; Cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; FBL1; FBXL1; FLB1; MGC1366; p45; p45skp2; S-phase kinase associated protein 2; S-phase kinase-associated protein 2; S-phase kinase-associated protein 2 (p45); S-phase kinase-associated protein 2, E3 ubiquitin protein ligase; SKP2

Gene Symbols: SKP2

Molecular weight: 47,761 Da

Basal Isoelectric point: 6.67 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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SKP2

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