COX2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. Belongs to the cytochrome c oxidase subunit 2 family. Note: This description may include information from UniProtKB.
Protein type: EC; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: -
Cellular Component:  integral component of membrane; mitochondrial inner membrane; mitochondrion; respiratory chain complex IV
Molecular Function:  copper ion binding; cytochrome-c oxidase activity; protein binding
Biological Process:  lactation; mitochondrial electron transport, cytochrome c to oxygen; positive regulation of ATP biosynthetic process; positive regulation of hydrogen peroxide biosynthetic process; positive regulation of necrotic cell death; proton transmembrane transport; response to cold
Disease: Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-like Episodes
Reference #:  P00403 (UniProtKB)
Alt. Names/Synonyms: COII; COX2; COXII; Cytochrome c oxidase polypeptide II; Cytochrome c oxidase subunit 2; cytochrome c oxidase subunit II; mitochondrially encoded cytochrome c oxidase II; MT-CO2; MTCO2
Gene Symbols: MT-CO2
Molecular weight: 25,565 Da
Basal Isoelectric point: 4.67  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene