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COX2
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. Belongs to the cytochrome c oxidase subunit 2 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase |
| Chromosomal Location of human Ortholog: - |
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Cellular Component:
mitochondrial inner membrane; mitochondrial respiratory chain complex IV; mitochondrion; respiratory chain complex IV
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Molecular Function:
copper ion binding; cytochrome-c oxidase activity; protein binding
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Biological Process:
ATP synthesis coupled electron transport; cellular respiration; lactation; mitochondrial electron transport, cytochrome c to oxygen; positive regulation of ATP biosynthetic process; positive regulation of hydrogen peroxide biosynthetic process; proton transmembrane transport
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Disease: Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-like Episodes
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Reference #:
P00403
(UniProtKB)
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Alt. Names/Synonyms: COII; COX2; COXII; Cytochrome c oxidase polypeptide II; Cytochrome c oxidase subunit 2; cytochrome c oxidase subunit II; mitochondrially encoded cytochrome c oxidase II; MT-CO2; MTCO2
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Gene Symbols: MT-CO2
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Molecular weight:
25,565 Da
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Basal Isoelectric point:
4.67
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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