HP1 alpha Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  chromocenter; histone deacetylase complex; histone methyltransferase complex; kinetochore; nuclear envelope; nuclear heterochromatin; nuclear pericentric heterochromatin; nucleolus; nucleoplasm; nucleus; pericentric heterochromatin; protein-containing complex; ribonucleoprotein complex; site of DNA damage; transcriptional repressor complex
Molecular Function:  chromatin binding; histone deacetylase binding; identical protein binding; methylated histone binding; protein binding; protein binding, bridging; protein homodimerization activity; protein-containing complex binding; repressing transcription factor binding; ribonucleoprotein complex binding
Biological Process:  blood coagulation; cellular response to DNA damage stimulus; negative regulation of G0 to G1 transition; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; viral process
Reference #:  P45973 (UniProtKB)
Alt. Names/Synonyms: Antigen p25; CBX5; chromobox 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); Chromobox protein homolog 5; epididymis luminal protein 25; HEL25; Heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HP1; HP1 alpha; HP1 alpha homolog; HP1-ALPHA; HP1A; HP1Hs alpha
Gene Symbols: CBX5
Molecular weight: 22,225 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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HP1 alpha

Protein Structure Not Found.

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