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neurabin 1
Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Protein phosphatase, regulatory subunit |
| Chromosomal Location of rat Ortholog: 4q13 |
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Cellular Component:
actin cytoskeleton; cortical actin cytoskeleton; cytoplasm; cytoskeleton; dendrite; dendritic spine; dendritic spine neck; filopodium; glutamatergic synapse; growth cone; growth cone lamellipodium; lamellipodium; neuromuscular junction; neuronal cell body; postsynaptic actin cytoskeleton; postsynaptic density
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Molecular Function:
actin filament binding; GTPase binding; identical protein binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase 1 binding; protein-containing complex binding; transmembrane transporter binding
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Biological Process:
actin filament organization; calcium-mediated signaling; cellular response to toxic substance; excitatory postsynaptic potential; modulation of chemical synaptic transmission; negative regulation of long-term synaptic potentiation; negative regulation of spontaneous neurotransmitter secretion; negative regulation of stress fiber assembly; nervous system development; neuron development; neuron projection development; positive regulation of dendritic spine development; positive regulation of long-term synaptic depression; positive regulation of neuron projection development; positive regulation of protein kinase activity; postsynaptic actin cytoskeleton organization; regulation of actin filament polymerization; regulation of dendritic spine morphogenesis; regulation of filopodium assembly; regulation of synapse assembly; regulation of synapse structural plasticity; synapse organization
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Reference #:
O35867
(UniProtKB)
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Alt. Names/Synonyms: actin-binding protein neurabin; Neb1; neurabin 1; Neurabin-1; Neurabin-I; Neural tissue-specific F-actin-binding protein I; p180; PP1bp175; Ppp1r9a; Protein phosphatase 1 regulatory subunit 9A; protein phosphatase 1, regulatory (inhibitor) subunit 9A
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Gene Symbols: Ppp1r9a
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Molecular weight:
122,735 Da
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Basal Isoelectric point:
5.05
Predict pI for various phosphorylation states
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