neurabin 1 Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 4q13
Cellular Component:  actin cytoskeleton; cell junction; cortical actin cytoskeleton; cytoplasm; cytoskeleton; cytosol; dendrite; dendritic spine; dendritic spine neck; filopodium; glutamatergic synapse; growth cone; growth cone lamellipodium; lamellipodium; neuromuscular junction; neuron projection; neuronal cell body; postsynaptic actin cytoskeleton; postsynaptic density; synapse
Molecular Function:  actin filament binding; GTPase binding; ion channel binding; protein binding; protein C-terminus binding; protein domain specific binding; protein homodimerization activity; protein kinase binding; protein phosphatase 1 binding; protein-containing complex binding
Biological Process:  actin filament organization; aging; calcium-mediated signaling; cellular response to toxic substance; excitatory postsynaptic potential; modulation of chemical synaptic transmission; negative regulation of long-term synaptic potentiation; negative regulation of spontaneous neurotransmitter secretion; negative regulation of stress fiber assembly; neuron development; neuron projection development; positive regulation of dendritic spine development; positive regulation of long-term synaptic depression; positive regulation of neuron projection development; positive regulation of protein kinase activity; postsynaptic actin cytoskeleton organization; regulation of actin filament polymerization; regulation of dendritic spine morphogenesis; regulation of filopodium assembly; regulation of synapse assembly; regulation of synapse structural plasticity
Reference #:  O35867 (UniProtKB)
Alt. Names/Synonyms: actin-binding protein neurabin; Neb1; neurabin 1; Neurabin-1; Neurabin-I; Neural tissue-specific F-actin-binding protein I; p180; PP1bp175; Ppp1r9a; Protein phosphatase 1 regulatory subunit 9A; protein phosphatase 1, regulatory (inhibitor) subunit 9A
Gene Symbols: Ppp1r9a
Molecular weight: 122,735 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
Select Structure to View Below

neurabin 1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene