STXBP4 Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 17q22
Cellular Component:  phagocytic vesicle
Molecular Function:  protein binding; syntaxin binding
Biological Process:  cellular response to DNA damage stimulus; cellular response to interferon-gamma; insulin receptor signaling pathway; positive regulation of cell cycle G1/S phase transition; positive regulation of keratinocyte proliferation; protein stabilization; protein targeting; regulation of glucose transmembrane transport; regulation of insulin secretion involved in cellular response to glucose stimulus
Reference #:  Q6ZWJ1 (UniProtKB)
Alt. Names/Synonyms: FLJ16496; MGC149829; MGC50337; STX4-interacting protein; STXB4; STXBP4; Synip; syntaxin 4 interacting protein; Syntaxin 4-interacting protein; syntaxin binding protein 4; Syntaxin-binding protein 4
Gene Symbols: STXBP4
Molecular weight: 61,662 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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STXBP4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene