PAX2 Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS. Interacts with ELGN3; the interaction targets PAX2 for destruction. Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 19 C3|19 38.09 cM
Cellular Component:  centriolar satellite; Golgi apparatus; lysosome; microtubule organizing center; nucleolus; nucleus; protein-containing complex; protein-DNA complex; transcription factor complex
Molecular Function:  C2H2 zinc finger domain binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; proximal promoter sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process:  brain morphogenesis; branching involved in ureteric bud morphogenesis; camera-type eye development; cell differentiation; cell fate determination; cellular response to glucose stimulus; cellular response to hydrogen peroxide; cellular response to mechanical stimulus; cellular response to retinoic acid; central nervous system development; cochlea development; cochlea morphogenesis; dopaminergic neuron differentiation; glial cell differentiation; inner ear morphogenesis; kidney development; mesenchymal to epithelial transition; mesenchymal to epithelial transition involved in metanephros morphogenesis; mesodermal cell fate specification; mesonephric duct development; mesonephric tubule development; mesonephric tubule formation; mesonephros development; metanephric collecting duct development; metanephric distal convoluted tubule development; metanephric epithelium development; metanephric mesenchymal cell differentiation; metanephric mesenchyme development; metanephric nephron tubule formation; metanephros development; multicellular organism development; negative regulation of apoptotic process; negative regulation of apoptotic process involved in metanephric collecting duct development; negative regulation of apoptotic process involved in metanephric nephron tubule development; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of cytolysis; negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis; negative regulation of mesenchymal cell apoptotic process involved in metanephros development; negative regulation of programmed cell death; negative regulation of reactive oxygen species metabolic process; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; nephric duct formation; neural tube closure; optic chiasma development; optic cup morphogenesis involved in camera-type eye development; optic nerve development; optic nerve morphogenesis; optic nerve structural organization; pancreas development; paramesonephric duct development; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; positive regulation of metanephric DCT cell differentiation; positive regulation of metanephric glomerulus development; positive regulation of optic nerve formation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; pronephric field specification; pronephros development; protein kinase B signaling; reactive oxygen species metabolic process; regulation of apoptotic process; regulation of metanephric nephron tubule epithelial cell differentiation; regulation of metanephros size; regulation of programmed cell death; regulation of transcription, DNA-templated; retinal pigment epithelium development; stem cell differentiation; transcription, DNA-templated; ureter development; ureter maturation; ureter morphogenesis; ureteric bud development; urogenital system development; vestibulocochlear nerve formation
Reference #:  P32114 (UniProtKB)
Alt. Names/Synonyms: paired box gene 2; Paired box protein Pax-2; Pax-2; Pax2
Gene Symbols: Pax2
Molecular weight: 44,580 Da
Basal Isoelectric point: 7.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PAX2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene