dynactin 1 Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitement to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation. Belongs to the dynactin 150 kDa subunit family. Brain. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 2p13.1
Cellular Component:  axon; cell cortex; cell cortex region; centriolar subdistal appendage; centriole; centrosome; cytoplasm; cytosol; dynactin complex; dynein complex; intermediate filament cytoskeleton; kinetochore; microtubule; microtubule associated complex; microtubule plus-end; neuron projection; neuronal cell body; nuclear envelope; spindle; spindle pole
Molecular Function:  dynein complex binding; microtubule binding; motor activity; protein binding; protein kinase binding; tau protein binding; tubulin binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; cell division; centriole-centriole cohesion; ciliary basal body-plasma membrane docking; ER to Golgi vesicle-mediated transport; establishment of mitotic spindle orientation; G2/M transition of mitotic cell cycle; IRE1-mediated unfolded protein response; maintenance of synapse structure; microtubule anchoring at centrosome; mitotic cell cycle; motor behavior; nervous system development; neuromuscular junction development; neuromuscular process; neuron cellular homeostasis; neuron projection maintenance; non-motile cilium assembly; nuclear envelope disassembly; positive regulation of microtubule nucleation; positive regulation of microtubule polymerization; positive regulation of neuromuscular junction development; regulation of G2/M transition of mitotic cell cycle; regulation of mitotic spindle organization; retrograde transport, endosome to Golgi; ventral spinal cord development
Disease: Amyotrophic Lateral Sclerosis 1; Neuronopathy, Distal Hereditary Motor, Type Viib; Perry Syndrome
Reference #:  Q14203 (UniProtKB)
Alt. Names/Synonyms: 150 kDa dynein-associated polypeptide; DAP-150; DCTN1; DP-150; dynactin 1; dynactin 1 (p150, glued homolog, Drosophila); Dynactin subunit 1; HMN7B; p135; p150, Glued homolog; p150-glued
Gene Symbols: DCTN1
Molecular weight: 141,695 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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dynactin 1

Protein Structure Not Found.

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