dynactin 1 Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitement to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation. Belongs to the dynactin 150 kDa subunit family. Brain. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of rat Ortholog: 4q34
Cellular Component:  cell cortex; cell cortex region; cell leading edge; centriolar subdistal appendage; centriole; centrosome; cytoplasm; cytoplasmic dynein complex; cytosol; dynactin complex; intermediate filament cytoskeleton; kinetochore; microtubule; microtubule associated complex; microtubule plus-end; neuron projection; neuronal cell body; nuclear envelope; protein-containing complex; spindle; spindle pole
Molecular Function:  dynein complex binding; identical protein binding; microtubule binding; motor activity; protein kinase binding; tubulin binding
Biological Process:  cell division; centriole-centriole cohesion; cytoplasmic microtubule organization; establishment of mitotic spindle orientation; melanosome transport; microtubule anchoring at centrosome; motor behavior; neuromuscular junction development; neuromuscular process; neuron cellular homeostasis; neuron projection maintenance; non-motile cilium assembly; nuclear envelope disassembly; positive regulation of intracellular protein transport; positive regulation of microtubule nucleation; positive regulation of microtubule polymerization; positive regulation of neuromuscular junction development; regulation of mitotic spindle organization; retrograde transport, endosome to Golgi; transport along microtubule; ventral spinal cord development
Reference #:  P28023 (UniProtKB)
Alt. Names/Synonyms: 150 kDa dynein-associated polypeptide; DAP-150; Dctn1; DP-150; dynactin 1; Dynactin subunit 1; p150-glued
Gene Symbols: Dctn1
Molecular weight: 141,930 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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dynactin 1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene