CNGB1 Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB1 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component:  photoreceptor outer segment membrane
Molecular Function:  cAMP binding; identical protein binding; protein binding; protein homodimerization activity
Biological Process:  response to stimulus; sensory perception of smell; visual perception
Reference #:  Q28181 (UniProtKB)
Alt. Names/Synonyms: 240 kDa protein of rod photoreceptor CNG-channel; CNCG4; CNG channel 4; CNG-4; CNGB1; cyclic nucleotide gated channel beta 1; Cyclic nucleotide-gated cation channel beta-1; cyclic nucleotide-gated cation channel modulatory subunit; GARP
Gene Symbols: CNGB1
Molecular weight: 155,065 Da
Basal Isoelectric point: 4.54  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein