ADAM10 Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3. May regulate the EFNA5-EPHA3 signaling. Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cell surface; EC; Membrane protein, integral; Motility/polarity/chemotaxis; Protease; Vesicle
Chromosomal Location of human Ortholog: 15q21.3
Cellular Component:  adherens junction; axon; cell surface; clathrin-coated vesicle; cytoplasm; dendrite; endoplasmic reticulum lumen; glutamatergic synapse; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; intracellular membrane-bounded organelle; membrane; nucleus; perinuclear endoplasmic reticulum; plasma membrane; pore complex; postsynaptic density; specific granule membrane; synaptic membrane; tertiary granule membrane; tetraspanin-enriched microdomain
Molecular Function:  endopeptidase activity; integrin binding; metal ion binding; metallodipeptidase activity; metalloendopeptidase activity; metalloendopeptidase activity involved in amyloid precursor protein catabolic process; metallopeptidase activity; molecular adaptor activity; protein binding; protein homodimerization activity; protein kinase binding; SH3 domain binding; signaling receptor binding
Biological Process:  adherens junction organization; amyloid precursor protein catabolic process; cell-cell signaling; cochlea development; constitutive protein ectodomain proteolysis; epidermal growth factor receptor ligand maturation; extracellular matrix disassembly; in utero embryonic development; integrin-mediated signaling pathway; membrane protein ectodomain proteolysis; monocyte activation; negative regulation of cell adhesion; negative regulation of gene expression; Notch signaling pathway; pore complex assembly; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of T cell chemotaxis; postsynapse organization; protein catabolic process at postsynapse; protein phosphorylation; protein processing; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of Notch signaling pathway; regulation of postsynapse organization; regulation of vasculature development; response to tumor necrosis factor; toxin transport
Disease: Alzheimer Disease 18; Reticulate Acropigmentation Of Kitamura
Reference #:  O14672 (UniProtKB)
Alt. Names/Synonyms: a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase domain 10; AD10; AD18; ADA10; ADAM 10; ADAM metallopeptidase domain 10; ADAM10; CD156c; CDw156; Disintegrin and metalloproteinase domain-containing protein 10; HsT18717; KUZ; Kuzbanian protein homolog; MADM; Mammalian disintegrin-metalloprotease; RAK
Gene Symbols: ADAM10
Molecular weight: 84,142 Da
Basal Isoelectric point: 8.04  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Notch Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein