PRKD1 a serine/threonine-protein kinase that converts transient signals initiated by PKC into prolonged physiological effects. Involved in Golgi membrane trafficking, cell survival, cell migration, cell differentiation, and cell proliferation. Plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells. Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. Note: This description may include information from UniProtKB.
Protein type: Autophagy; CAMK group; EC 2.7.11.13; Kinase, protein; Motility/polarity/chemotaxis; PKD family; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 6q22
Cellular Component:  autophagosome membrane; cell cortex; cell-cell junction; cytoplasm; cytosol; Golgi apparatus; nucleus; plasma membrane; trans-Golgi network
Molecular Function:  ATP binding; identical protein binding; kinase activity; metal ion binding; protein kinase C activity; protein serine/threonine kinase activity
Biological Process:  angiogenesis; apoptotic process; cellular response to amino acid starvation; cellular response to hydroperoxide; cellular response to oxidative stress; cellular response to vascular endothelial growth factor stimulus; defense response to Gram-negative bacterium; Golgi organization; Golgi vesicle transport; inflammatory response; innate immune response; intracellular signal transduction; negative regulation of cell death; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of angiogenesis; positive regulation of autophagy; positive regulation of blood vessel endothelial cell migration; positive regulation of CREB transcription factor activity; positive regulation of endothelial cell chemotaxis; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of histone deacetylase activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; positive regulation of osteoblast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein import into nucleus; positive regulation of transcription by RNA polymerase II; protein autophosphorylation; protein kinase D signaling; protein phosphorylation; Ras protein signal transduction; regulation of keratinocyte proliferation; regulation of protein stability; regulation of release of sequestered calcium ion into cytosol; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q9WTQ1 (UniProtKB)
Alt. Names/Synonyms: KPCD1; nPKC-D1; nPKC-mu; Pkcm; Pkd; Prkcm; Prkd1; Protein kinase C mu type; protein kinase C, mu; Protein kinase D; protein kinase D1; Serine/threonine-protein kinase D1
Gene Symbols: Prkd1
Molecular weight: 102,043 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PRKD1

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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein