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UBE2E2
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. Belongs to the ubiquitin-conjugating enzyme family. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of rat Ortholog: 15p16 |
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Cellular Component:
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Molecular Function:
ATP binding; ISG15 transferase activity; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity
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Biological Process:
DNA damage response; ISG15-protein conjugation; positive regulation of G1/S transition of mitotic cell cycle; protein K11-linked ubiquitination; protein K48-linked ubiquitination; protein K63-linked ubiquitination
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Reference #:
NP_001101841
(RefSeq)
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Alt. Names/Synonyms: Ube2e2; ubiquitin-conjugating enzyme E2 E2; ubiquitin-conjugating enzyme E2E 2; ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
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Gene Symbols: Ube2e2
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Molecular weight:
20,336 Da
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Basal Isoelectric point:
8.31
Predict pI for various phosphorylation states
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