adrenodoxin Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. Belongs to the adrenodoxin/putidaredoxin family. Highest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at protein level). Note: This description may include information from UniProtKB.
Protein type: Mitochondrial
Cellular Component:  mitochondrial matrix; mitochondrion
Molecular Function:  2 iron, 2 sulfur cluster binding; electron transfer activity; metal ion binding; protein binding; protein C-terminus binding; protein homodimerization activity
Biological Process:  cellular response to cAMP; cellular response to forskolin; cholesterol metabolic process; electron transport chain; hormone biosynthetic process; oxidation-reduction process; steroid biosynthetic process
Reference #:  P00257 (UniProtKB)
Alt. Names/Synonyms: Adrenal ferredoxin; adrenodoxin; Adrenodoxin, mitochondrial; ADX; ADX1; BOS_14312; FDX1; ferredoxin 1; Hepato- ferredoxin
Gene Symbols: FDX1
Molecular weight: 19,756 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
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adrenodoxin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene