TAK1 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ASK subfamily; EC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; STE group; STE11 family
Chromosomal Location of rat Ortholog: 5q21
Cellular Component:  ATAC complex; cytoplasm; cytosol; IkappaB kinase complex; plasma membrane; postsynaptic density
Molecular Function:  ATP binding; DNA-binding transcription factor binding; histone kinase activity; identical protein binding; linear polyubiquitin binding; magnesium ion binding; MAP kinase activity; MAP kinase kinase activity; MAP kinase kinase kinase activity; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase binding; receptor tyrosine kinase binding; scaffold protein binding; transcription coactivator binding; type II transforming growth factor beta receptor binding; ubiquitin protein ligase binding
Biological Process:  activation of NF-kappaB-inducing kinase activity; angiogenesis; anoikis; apoptotic process; apoptotic signaling pathway; bone development; cellular response to angiotensin; cellular response to oxygen-glucose deprivation; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; chromatin remodeling; histone H3 acetylation; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; immune response; inflammatory response; interleukin-17A-mediated signaling pathway; JNK cascade; MAPK cascade; negative regulation of apoptotic signaling pathway; negative regulation of gene expression; negative regulation of necroptotic process; negative regulation of reactive oxygen species metabolic process; negative regulation of ripoptosome assembly involved in necroptotic process; negative regulation of voltage-gated calcium channel activity; neural tube formation; osteoblast differentiation; peptidyl-threonine phosphorylation; positive regulation of autophagy; positive regulation of cell cycle; positive regulation of cell size; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-2 production; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of macroautophagy; positive regulation of MAPK cascade; positive regulation of T cell cytokine production; positive regulation of vascular associated smooth muscle cell migration; positive regulation of vascular associated smooth muscle cell proliferation; protein phosphorylation; regulation of reactive oxygen species metabolic process; response to angiotensin; response to hypoxia; stress-activated MAPK cascade; toll-like receptor 4 signaling pathway; transforming growth factor beta receptor signaling pathway
Reference #:  P0C8E4 (UniProtKB)
Alt. Names/Synonyms: M3K7; Map3k7; mitogen activated protein kinase kinase kinase 7; Mitogen-activated protein kinase kinase kinase 7; Tak1; TGF-beta activated kinase 1
Gene Symbols: Map3k7
Molecular weight: 67,200 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein