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BRCA2
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination. Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen. Note: This description may include information from UniProtKB.
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| Protein type: DNA repair, damage; Nuclear receptor co-regulator; Tumor suppressor |
| Chromosomal Location of mouse Ortholog: 5 G3|5 89.52 cM |
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Cellular Component:
BRCA2-MAGE-D1 complex; centrosome; chromosome; chromosome, telomeric region; cytoplasm; cytoskeleton; cytosol; DNA repair complex; lateral element; nuclear ubiquitin ligase complex; nucleoplasm; nucleus; protein-containing complex; secretory granule
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Molecular Function:
DNA binding; gamma-tubulin binding; histone H3 acetyltransferase activity; histone H4 acetyltransferase activity; identical protein binding; protease binding; protein binding; single-stranded DNA binding
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Biological Process:
brain development; cell cycle; cell population proliferation; cellular response to ionizing radiation; cellular senescence; centrosome duplication; chordate embryonic development; chromosome organization; DNA damage response; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA recombination; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; establishment of protein localization to telomere; female gonad development; hematopoietic stem cell proliferation; hemopoiesis; histone H2A monoubiquitination; homologous chromosome orientation involved in meiotic metaphase I plate congression; inner cell mass cell proliferation; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; male meiosis I; mammary gland development; mitotic recombination-dependent replication fork processing; multicellular organism growth; negative regulation of mammary gland epithelial cell proliferation; nucleotide-excision repair; oocyte maturation; positive regulation of DNA-templated transcription; positive regulation of mitotic cell cycle; protein autoubiquitination; regulation of cytokinesis; regulation of DNA damage checkpoint; regulation of DNA-templated transcription; replication fork processing; response to gamma radiation; response to UV-C; response to X-ray; spermatogenesis; stem cell proliferation; telomere maintenance via recombination
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Reference #:
P97929
(UniProtKB)
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Alt. Names/Synonyms: AI256696; AW045498; Brca2; breast cancer 2; breast cancer 2, early onset; Breast cancer type 2 susceptibility protein homolog; Fanc; Fancd1; Fanconi anemia group D1 protein homolog; RAB1; RAB163
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Gene Symbols: Brca2
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Molecular weight:
370,664 Da
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Basal Isoelectric point:
6.23
Predict pI for various phosphorylation states
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