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AurC iso2
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: AUR family; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 19q13.43 |
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Cellular Component:
chromosome passenger complex; condensed chromosome; cytoplasm; kinetochore; midbody; nucleus; spindle; spindle microtubule; spindle midzone; spindle pole centrosome
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Molecular Function:
ATP binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity
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Biological Process:
attachment of spindle microtubules to kinetochore; cell division; histone modification; meiotic cell cycle; mitotic spindle midzone assembly; mitotic spindle organization; positive regulation of cytokinesis; protein phosphorylation; regulation of cytokinesis
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Disease: Spermatogenic Failure 5
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Reference #:
Q9UQB9-2
(UniProtKB)
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Alt. Names/Synonyms: AIE2; AIK3; AIRK3; ARK-3; ARK3; AurC; AurC iso2; AURKC; Aurora 3; Aurora C; Aurora kinase C; aurora-C; Aurora-related kinase 3; Aurora/IPL1-related kinase 3; Aurora/IPL1/Eg2 protein 2; epididymis secretory protein Li 90; HEL-S-90; serine/threonine kinase 13 (aurora/IPL1-like); Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C; SPGF5; STK13
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Gene Symbols: AURKC
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Molecular weight:
32,187 Da
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Basal Isoelectric point:
8.97
Predict pI for various phosphorylation states
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