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PRKD3
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; EC 2.7.11.13; Kinase, protein; PKD family; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 2p22.2 |
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Cellular Component:
cytosol; membrane; nucleoplasm
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Molecular Function:
ATP binding; calcium-dependent protein kinase C activity; kinase activity; metal ion binding; protein binding; protein kinase C activity; protein serine kinase activity
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Biological Process:
protein kinase C-activating G protein-coupled receptor signaling pathway; protein kinase D signaling; protein phosphorylation; sphingolipid biosynthetic process
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Reference #:
O94806
(UniProtKB)
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Alt. Names/Synonyms: EPK2; KPCD3; nPKC-nu; PKC-NU; PKD3; PRKCN; PRKD3; Protein kinase C nu type; protein kinase C, nu; protein kinase D3; Protein kinase EPK2; Serine/threonine-protein kinase D3
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Gene Symbols: PRKD3
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Molecular weight:
100,471 Da
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Basal Isoelectric point:
6.42
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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B Cell Receptor Signaling
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ErbB/HER Signaling
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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Inhibition of Apoptosis
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Mitochondrial Control of Apoptosis
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Phospholipase Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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