DOK6 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance. Belongs to the DOK family. Type B subfamily. Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 18q22.2
Cellular Component:  cytoplasm; cytosol
Molecular Function:  protein binding
Biological Process:  positive regulation of MAPK cascade; Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q6PKX4 (UniProtKB)
Alt. Names/Synonyms: docking protein 5-like; Docking protein 6; DOK5L; DOK6; Downstream of tyrosine kinase 6; HsT3226; MGC20785
Gene Symbols: DOK6
Molecular weight: 38,318 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein