DOK6
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance. Belongs to the DOK family. Type B subfamily. Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold |
Chromosomal Location of human Ortholog: 18q22.2 |
Cellular Component:
cytoplasm; cytosol
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Molecular Function:
protein binding
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Biological Process:
positive regulation of MAPK cascade; Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
Q6PKX4
(UniProtKB)
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Alt. Names/Synonyms: docking protein 5-like; Docking protein 6; DOK5L; DOK6; Downstream of tyrosine kinase 6; HsT3226; MGC20785
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Gene Symbols: DOK6
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Molecular weight:
38,318 Da
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Basal Isoelectric point:
8.72
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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