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Kv4.3
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of mouse Ortholog: 3|3 F2.2 |
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Cellular Component:
caveola; cell projection; dendrite; dendritic spine; GABA-ergic synapse; membrane; neuronal cell body; perinuclear endoplasmic reticulum; plasma membrane; postsynaptic membrane; postsynaptic specialization membrane; potassium channel complex; voltage-gated potassium channel complex
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Molecular Function:
A-type (transient outward) potassium channel activity; metal ion binding; monoatomic ion channel activity; potassium channel activity; protein binding; transmembrane transporter binding; voltage-gated monoatomic ion channel activity; voltage-gated potassium channel activity; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
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Biological Process:
cellular response to BMP stimulus; membrane repolarization; monoatomic ion transport; potassium ion export across plasma membrane; potassium ion import across plasma membrane; potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; regulation of heart rate by cardiac conduction; regulation of monoatomic ion transmembrane transport; transmembrane transport; ventricular cardiac muscle cell membrane repolarization
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Reference #:
Q9Z0V1
(UniProtKB)
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Alt. Names/Synonyms: AW045978; Kcnd3; Kncd3; Kv4.; Kv4.3; potassium channel Kv4.3L; potassium channel Kv4.3M; Potassium voltage-gated channel subfamily D member 3; potassium voltage-gated channel, Shal-related family, member 3; Voltage-gated potassium channel subunit Kv4.3
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Gene Symbols: Kcnd3
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Molecular weight:
73,462 Da
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Basal Isoelectric point:
8.56
Predict pI for various phosphorylation states
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