Kv4.3 Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3|3 F2.2
Cellular Component:  caveola; cell projection; dendrite; GABA-ergic synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic specialization membrane; membrane; neuron projection; neuronal cell body; perinuclear endoplasmic reticulum; plasma membrane; potassium channel complex; voltage-gated potassium channel complex
Molecular Function:  A-type (transient outward) potassium channel activity; ion channel activity; ion channel binding; metal ion binding; potassium channel activity; protein binding; voltage-gated ion channel activity; voltage-gated potassium channel activity
Biological Process:  cellular response to BMP stimulus; ion transport; membrane repolarization; potassium ion export across plasma membrane; potassium ion import across plasma membrane; potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; regulation of heart rate by cardiac conduction; regulation of ion transmembrane transport; transmembrane transport; ventricular cardiac muscle cell membrane repolarization
Reference #:  Q9Z0V1 (UniProtKB)
Alt. Names/Synonyms: AW045978; Kcnd3; Kncd3; Kv4.; Kv4.3; potassium channel Kv4.3L; potassium channel Kv4.3M; Potassium voltage-gated channel subfamily D member 3; potassium voltage-gated channel, Shal-related family, member 3; Voltage-gated potassium channel subunit Kv4.3
Gene Symbols: Kcnd3
Molecular weight: 73,462 Da
Basal Isoelectric point: 8.56  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene