IL2RA Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of human Ortholog: 10p15.1
Cellular Component:  external side of plasma membrane; interleukin-2 receptor complex; plasma membrane
Molecular Function:  interleukin-2 binding; interleukin-2 receptor activity; protein binding
Biological Process:  activated T cell proliferation; activation-induced cell death of T cells; apoptotic process; cell surface receptor signaling pathway; immune response; inflammatory response; inflammatory response to antigenic stimulus; interleukin-2-mediated signaling pathway; negative regulation of inflammatory response; negative regulation of T cell proliferation; Notch signaling pathway; positive regulation of activated T cell proliferation; positive regulation of T cell differentiation; regulation of CD4-positive, alpha-beta T cell proliferation; regulation of T cell homeostatic proliferation; regulation of T cell tolerance induction
Disease: Diabetes Mellitus, Insulin-dependent, 10; Interleukin 2 Receptor, Alpha, Deficiency Of
Reference #:  P01589 (UniProtKB)
Alt. Names/Synonyms: CD25; IDDM10; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; IL2R; IL2RA; IMD41; interleukin 2 receptor subunit alpha; interleukin 2 receptor, alpha; Interleukin-2 receptor subunit alpha; p55; TAC antigen; TCGFR
Gene Symbols: IL2RA
Molecular weight: 30,819 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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IL2RA

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene