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IL2RA
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of human Ortholog: 10p15.1 |
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Cellular Component:
external side of plasma membrane; interleukin-2 receptor complex; plasma membrane
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Molecular Function:
interleukin-2 binding; interleukin-2 receptor activity; protein binding
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Biological Process:
activated T cell proliferation; activation-induced cell death of T cells; apoptotic process; cell surface receptor signaling pathway; immune response; inflammatory response; inflammatory response to antigenic stimulus; interleukin-2-mediated signaling pathway; negative regulation of inflammatory response; negative regulation of T cell proliferation; Notch signaling pathway; positive regulation of activated T cell proliferation; positive regulation of T cell differentiation; regulation of CD4-positive, alpha-beta T cell proliferation; regulation of T cell homeostatic proliferation; regulation of T cell tolerance induction
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Disease: Diabetes Mellitus, Insulin-dependent, 10; Interleukin 2 Receptor, Alpha, Deficiency Of
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Reference #:
P01589
(UniProtKB)
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Alt. Names/Synonyms: CD25; IDDM10; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; IL2R; IL2RA; IMD41; interleukin 2 receptor subunit alpha; interleukin 2 receptor, alpha; Interleukin-2 receptor subunit alpha; p55; TAC antigen; TCGFR
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Gene Symbols: IL2RA
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Molecular weight:
30,819 Da
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Basal Isoelectric point:
6.11
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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