ABCB1 Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Expressed in liver, kidney, small intestine and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; EC 3.6.3.44; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of human Ortholog: 7q21.12
Cellular Component:  apical plasma membrane; cell surface; membrane; plasma membrane
Molecular Function:  ATP binding; ceramide-translocating ATPase activity; phosphatidylcholine-translocating ATPase activity; phosphatidylethanolamine-translocating ATPase activity; protein binding
Biological Process:  ceramide translocation; G2/M transition of mitotic cell cycle; phospholipid translocation; positive regulation of anion channel activity; regulation of chloride transport; regulation of response to osmotic stress; response to drug; stem cell proliferation; transmembrane transport
Disease: Colchicine Resistance; Inflammatory Bowel Disease 13
Reference #:  P08183 (UniProtKB)
Alt. Names/Synonyms: ABC20; ABCB1; ATP binding cassette subfamily B member 1; ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, subfamily B, member 1; ATP-dependent translocase ABCB1; CD243; CLCS; colchicin sensitivity; doxorubicin resistance; GP170; MDR1; MGC163296; Multidrug resistance protein 1; P-glycoprotein 1; P-GP; PGY1; Phospholipid transporter ABCB1
Gene Symbols: ABCB1
Molecular weight: 141,479 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ABCB1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene