UBQLN2 Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs). Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: Xp11.21
Cellular Component:  autophagosome; cytoplasm; cytoplasmic vesicle; cytosol; nucleus; plasma membrane
Molecular Function:  protein binding
Biological Process:  negative regulation of clathrin-dependent endocytosis; negative regulation of G protein-coupled receptor internalization; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; regulation of autophagosome assembly; regulation of macroautophagy; ubiquitin-dependent ERAD pathway
Disease: Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia
Reference #:  Q9UHD9 (UniProtKB)
Alt. Names/Synonyms: ALS15; Chap1; DSK2; DSK2 homolog; FLJ10167; FLJ56541; hPLIC-2; HRIHFB2157; N4BP4; Nedd4 binding protein 4; PLIC-2; PLIC2; Protein linking IAP with cytoskeleton 2; ubiquilin 2; Ubiquilin-2; Ubiquitin-like product Chap1/Dsk2; UBQL2; UBQLN2
Gene Symbols: UBQLN2
Molecular weight: 65,696 Da
Basal Isoelectric point: 5.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene