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UBQLN2
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs). Note: This description may include information from UniProtKB.
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| Protein type: Ubiquitin conjugating system |
| Chromosomal Location of human Ortholog: Xp11.21 |
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Cellular Component:
autophagosome; cytoplasm; cytoplasmic vesicle; cytosol; nucleus; plasma membrane
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Molecular Function:
identical protein binding; molecular condensate scaffold activity; polyubiquitin modification-dependent protein binding; protein binding
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Biological Process:
autophagosome assembly; negative regulation of clathrin-dependent endocytosis; negative regulation of G protein-coupled receptor internalization; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; regulation of autophagosome assembly; regulation of macroautophagy; ubiquitin-dependent ERAD pathway
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Disease: Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia
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Reference #:
Q9UHD9
(UniProtKB)
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Alt. Names/Synonyms: ALS15; Chap1; DSK2; DSK2 homolog; FLJ10167; FLJ56541; hPLIC-2; HRIHFB2157; N4BP4; Nedd4 binding protein 4; PLIC-2; PLIC2; Protein linking IAP with cytoskeleton 2; ubiquilin 2; Ubiquilin-2; Ubiquitin-like product Chap1/Dsk2; UBQL2; UBQLN2
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Gene Symbols: UBQLN2
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Molecular weight:
65,696 Da
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Basal Isoelectric point:
5.15
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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