acinus an ubiquitous RNA-binding protein. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC is composed of ACIN1, CASC3, DDX48, MAGOH, PNN, RBM8A, RNPS1, SAP18 and THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Interacts with API5. Phosphorylation by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm, and up-regulates its stimulatory effect on cyclin A1. Activated by proteolytic cleavage. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. Four alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 14|14 C2
Cellular Component:  ASAP complex; cytosol; nuclear speck; nucleolus; nucleoplasm; nucleus; plasma membrane
Molecular Function:  nucleic acid binding
Biological Process:  apoptotic chromosome condensation; apoptotic process; mRNA processing; negative regulation of mRNA splicing, via spliceosome; positive regulation of apoptotic process; RNA splicing
Reference #:  Q9JIX8 (UniProtKB)
Alt. Names/Synonyms: 2610036I19Rik; 2610510L13Rik; Acin1; ACINU; Acinus; acinusL; acinusS; Acn; apoptotic chromatin condensation inducer 1; Apoptotic chromatin condensation inducer in the nucleus; C79325; mKIAA0670
Gene Symbols: Acin1
Molecular weight: 150,719 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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acinus

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene