CTBP1 Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Expressed in germinal center B-cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5 B1|5 17.52 cM
Cellular Component:  cytoplasm; GABA-ergic synapse; glutamatergic synapse; nucleoplasm; nucleus; presynapse; presynaptic active zone cytoplasmic component; transcription factor complex; transcriptional repressor complex
Molecular Function:  DNA-binding transcription factor activity; identical protein binding; NAD binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; PDZ domain binding; protein binding; protein domain specific binding; protein homodimerization activity; repressing transcription factor binding; transcription corepressor activity; transcription factor binding
Biological Process:  cell differentiation; chromatin silencing; negative regulation of histone acetylation; negative regulation of histone H4 acetylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; oxidation-reduction process; positive regulation of histone deacetylation; presynapse to nucleus signaling pathway; regulation of cell cycle; white fat cell differentiation
Reference #:  O88712 (UniProtKB)
Alt. Names/Synonyms: BARS; C-terminal binding protein 1; C-terminal-binding protein 1; CtBP1; CtBP1-L; CtBP1-S; CtBP3/; CtBP3/BARS; D4S115; D4S115h; D5H4S11; D5H4S115; D5H4S115E
Gene Symbols: Ctbp1
Molecular weight: 47,745 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA