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CTBP1
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Expressed in germinal center B-cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 4p16.3 |
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Cellular Component:
GABA-ergic synapse; glutamatergic synapse; nucleoplasm; nucleus; presynaptic active zone cytoplasmic component; transcription repressor complex
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Molecular Function:
chromatin binding; DNA-binding transcription factor binding; identical protein binding; NAD binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein binding; protein domain specific binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription coactivator activity; transcription coregulator binding; transcription corepressor activity; transcription corepressor binding
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Biological Process:
heterochromatin formation; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of histone acetylation; negative regulation of histone H4 acetylation; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; positive regulation of histone deacetylation; protein phosphorylation; regulation of cell cycle; regulation of transcription by RNA polymerase II; synaptic vesicle clustering; synaptic vesicle endocytosis; viral genome replication; white fat cell differentiation
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Disease: Hypotonia, Ataxia, Developmental Delay, And Tooth Enamel Defect Syndrome; Wolf-hirschhorn Syndrome
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Reference #:
Q13363
(UniProtKB)
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Alt. Names/Synonyms: BARS; brefeldin A-ribosylated substrate; C-terminal binding protein 1; C-terminal-binding protein 1; CTBP; CTBP1; HADDTS; MGC104684
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Gene Symbols: CTBP1
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Molecular weight:
47,535 Da
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Basal Isoelectric point:
6.28
Predict pI for various phosphorylation states
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CST Pathways:
Notch Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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