CTBP1 Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Expressed in germinal center B-cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component:  GABA-ergic synapse; glutamatergic synapse; nucleoplasm; nucleus; presynaptic active zone cytoplasmic component; transcription factor complex; transcriptional repressor complex
Molecular Function:  DNA-binding transcription factor activity; NAD binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein binding; protein C-terminus binding; protein domain specific binding; repressing transcription factor binding; transcription corepressor activity; transcription factor binding
Biological Process:  chromatin silencing; negative regulation of cell proliferation; negative regulation of histone acetylation; negative regulation of histone H4 acetylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; oxidation-reduction process; positive regulation of histone deacetylation; protein phosphorylation; regulation of cell cycle; viral genome replication; white fat cell differentiation
Disease: Hypotonia, Ataxia, Developmental Delay, And Tooth Enamel Defect Syndrome; Wolf-hirschhorn Syndrome
Reference #:  Q13363 (UniProtKB)
Alt. Names/Synonyms: BARS; brefeldin A-ribosylated substrate; C-terminal binding protein 1; C-terminal-binding protein 1; CTBP; CTBP1; HADDTS; MGC104684
Gene Symbols: CTBP1
Molecular weight: 47,535 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB