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CTBP1
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Expressed in germinal center B-cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor |
| Chromosomal Location of Human Ortholog: 4p16.3 |
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Cellular Component:
GABA-ergic synapse; glutamatergic synapse; nucleoplasm; nucleus; presynaptic active zone cytoplasmic component; transcription factor complex; transcriptional repressor complex
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Molecular Function:
DNA-binding transcription factor activity; NAD binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein binding; protein C-terminus binding; protein domain specific binding; repressing transcription factor binding; transcription corepressor activity; transcription factor binding
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Biological Process:
chromatin silencing; negative regulation of cell proliferation; negative regulation of histone acetylation; negative regulation of histone H4 acetylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; oxidation-reduction process; positive regulation of histone deacetylation; protein phosphorylation; regulation of cell cycle; viral genome replication; white fat cell differentiation
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Disease: Hypotonia, Ataxia, Developmental Delay, And Tooth Enamel Defect Syndrome; Wolf-hirschhorn Syndrome
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Reference #:
Q13363
(UniProtKB)
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Alt. Names/Synonyms: BARS; brefeldin A-ribosylated substrate; C-terminal binding protein 1; C-terminal-binding protein 1; CTBP; CTBP1; HADDTS; MGC104684
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Gene Symbols: CTBP1
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Molecular weight:
47,535 Da
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Basal Isoelectric point:
6.28
Predict pI for various phosphorylation states
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CST Pathways:
Notch Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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