DSPP DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals. Expressed in teeth. DPP is synthesized by odontoblast and transiently expressed by pre-ameloblasts. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component:  cytoplasm; extracellular matrix; extracellular region
Molecular Function:  calcium ion binding; extracellular matrix structural constituent
Biological Process:  biomineral tissue development; extracellular matrix organization; multicellular organism development; ossification; regulation of odontoblast differentiation; skeletal system development
Disease: Deafness, Autosomal Dominant 39, With Dentinogenesis Imperfecta 1; Dentin Dysplasia, Type Ii; Dentinogenesis Imperfecta 1; Dentinogenesis Imperfecta, Shields Type Iii
Reference #:  Q9NZW4 (UniProtKB)
Alt. Names/Synonyms: deafness, autosomal dominant 39; Dentin phosphophoryn; Dentin phosphoprotein; dentin phosphoryn; Dentin sialophosphoprotein; Dentin sialoprotein; DFNA39; DGI1; DMP3; DPP; DSP; DSPP; DTDP2
Gene Symbols: DSPP
Molecular weight: 131,151 Da
Basal Isoelectric point: 3.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene