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MP20
Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. Belongs to the PMP-22/EMP/MP20 family. Eye lens specific. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 19q13.41 |
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Cellular Component:
cell junction; plasma membrane; vesicle
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Molecular Function:
structural constituent of eye lens
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Biological Process:
cell-cell junction assembly; lens development in camera-type eye
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Disease: Cataract 19
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Reference #:
P55344
(UniProtKB)
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Alt. Names/Synonyms: CTRCT19; Lens fiber membrane intrinsic protein; lens intrinsic membrane protein 2; lens intrinsic membrane protein 2, 19kDa; LIM2; LMIP; MP17; MP18; MP19; MP20
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Gene Symbols: LIM2
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Molecular weight:
19,674 Da
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Basal Isoelectric point:
9.64
Predict pI for various phosphorylation states
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