Spinophilin Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1. Required for hepatocyte growth factor (HGF)-induced cell migration. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Protein phosphatase, regulatory subunit
Chromosomal Location of mouse Ortholog: 11|11 D
Cellular Component:  actin cytoskeleton; cell junction; cell projection; cortical actin cytoskeleton; cytoplasm; cytoplasmic side of dendritic spine plasma membrane; cytoskeleton; dendrite; dendritic spine; dendritic spine head; dendritic spine membrane; dendritic spine neck; filopodium; growth cone; lamellipodium; membrane; neuron projection; neuronal cell body; nucleoplasm; nucleus; plasma membrane; postsynaptic density; ruffle membrane; synapse
Molecular Function:  actin binding; actin filament binding; D2 dopamine receptor binding; kinase binding; protein binding; protein C-terminus binding; protein kinase activity; protein phosphatase 1 binding; protein phosphatase inhibitor activity; protein-containing complex binding; transmembrane transporter binding
Biological Process:  actin cytoskeleton organization; actin filament organization; calcium-mediated signaling; cell differentiation; cell migration; cellular response to morphine; dendrite development; filopodium assembly; modulation of chemical synaptic transmission; multicellular organism development; negative regulation of cell growth; negative regulation of phosphoprotein phosphatase activity; nervous system development; neuron projection development; positive regulation of protein localization; positive regulation of protein localization to actin cortical patch; positive regulation of protein localization to plasma membrane; protein localization to actin cytoskeleton; protein localization to cell periphery; regulation of cell population proliferation; regulation of opioid receptor signaling pathway; regulation of protein phosphorylation
Reference #:  Q6R891 (UniProtKB)
Alt. Names/Synonyms: MGC38940; NEB2; neurabin II; Neurabin-2; Neurabin-II; OTTMUSP00000001457; Ppp1r9b; Protein phosphatase 1 regulatory subunit 9B; protein phosphatase 1, regulatory subunit 9B; Spinophilin; SPL; Spn
Gene Symbols: Ppp1r9b
Molecular weight: 89,520 Da
Basal Isoelectric point: 4.86  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Spinophilin

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene