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Kv4.3
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of rat Ortholog: 2q34 |
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Cellular Component:
caveola; dendrite; dendritic spine; GABA-ergic synapse; membrane; neuron projection; neuronal cell body; perinuclear endoplasmic reticulum; plasma membrane; postsynaptic density; postsynaptic membrane; postsynaptic specialization membrane; potassium channel complex; sarcolemma; voltage-gated potassium channel complex
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Molecular Function:
A-type (transient outward) potassium channel activity; ion channel activity; metal ion binding; potassium channel activity; protein binding; transmembrane transporter binding; voltage-gated potassium channel activity; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
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Biological Process:
cardiac muscle cell action potential involved in contraction; cell communication involved in cardiac conduction; cellular response to BMP stimulus; establishment of localization in cell; membrane repolarization; membrane repolarization during ventricular cardiac muscle cell action potential; potassium ion export across plasma membrane; potassium ion import across plasma membrane; potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; regulation of heart rate by cardiac conduction; regulation of ion transmembrane transport; ventricular cardiac muscle cell membrane repolarization
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Reference #:
Q62897
(UniProtKB)
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Alt. Names/Synonyms: Kcnd3; Kv4.3; potassium voltage gated channel, Shal-related family, member 3; Potassium voltage-gated channel subfamily D member 3; Voltage-gated potassium channel subunit Kv4.3
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Gene Symbols: Kcnd3
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Molecular weight:
73,513 Da
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Basal Isoelectric point:
8.56
Predict pI for various phosphorylation states
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