CDK14 Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/PCTAIRE subfamily; CMGC group; Cell cycle regulation; EC; Kinase, protein; Motility/polarity/chemotaxis; PFTAIRE subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 7q21.13
Cellular Component:  cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoplasmic cyclin-dependent protein kinase holoenzyme complex; cytosol; nucleoplasm; nucleus; plasma membrane
Molecular Function:  ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; protein binding; protein serine kinase activity
Biological Process:  cell division; G2/M transition of mitotic cell cycle; protein phosphorylation; regulation of canonical Wnt signaling pathway; regulation of cell cycle; regulation of transcription involved in G1/S transition of mitotic cell cycle; Wnt signaling pathway
Reference #:  O94921 (UniProtKB)
Alt. Names/Synonyms: CDK14; Cell division protein kinase 14; cyclin dependent kinase 14; Cyclin-dependent kinase 14; hPFTAIRE1; KIAA0834; PFTAIRE protein kinase 1; PFTAIRE1; PFTK1; Serine/threonine-protein kinase PFTAIRE-1
Gene Symbols: CDK14
Molecular weight: 53,057 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein