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claspin
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. Belongs to the claspin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Cell cycle regulation |
| Chromosomal Location of Human Ortholog: 1p34.3 |
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Cellular Component:
Golgi apparatus; nucleoplasm
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Molecular Function:
anaphase-promoting complex binding; DNA binding; protein binding
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Biological Process:
activation of protein kinase activity; DNA damage checkpoint; DNA repair; DNA replication; mitotic DNA replication checkpoint; mitotic G2 DNA damage checkpoint; peptidyl-serine phosphorylation; protein deubiquitination
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Reference #:
Q9HAW4
(UniProtKB)
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Alt. Names/Synonyms: Claspin; claspin homolog (Xenopus laevis); CLSPN; hClaspin; MGC131612; MGC131613; MGC131615
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Gene Symbols: CLSPN
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Molecular weight:
151,094 Da
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Basal Isoelectric point:
4.74
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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