TCEB1 SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells. The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. Belongs to the SKP1 family. Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription initiation complex
Chromosomal Location of mouse Ortholog: 1|1 A3
Cellular Component:  Cul5-RING ubiquitin ligase complex; cytosol; elongin complex; nucleus; VCB complex
Molecular Function:  protein binding; protein-containing complex binding; protein-macromolecule adaptor activity; transcription corepressor binding
Biological Process:  protein ubiquitination; target-directed miRNA degradation; transcription initiation at RNA polymerase II promoter; ubiquitin-dependent protein catabolic process
Reference #:  P83940 (UniProtKB)
Alt. Names/Synonyms: 2610043E24Rik; 2610301I15Rik; AA407206; AI987979; AW049146; EloC; Elongin 15 kDa subunit; elongin C; Elongin-C; RNA polymerase II transcription factor SIII subunit C; SIII p15; Stromal membrane-associated protein SMAP1B homolog; Tceb1; transcription elongation factor B (SIII), polypeptide 1; Transcription elongation factor B polypeptide 1
Gene Symbols: Eloc
Molecular weight: 12,473 Da
Basal Isoelectric point: 4.74  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein