UBE3A E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator p27Kip1. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Binds UBQLN1 and UBQLN2. Interacts with the 26S proteasome. Interacts with HCV core protein and targets it to degradation. Interacts with the E6 protein of the cancer- associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the p53/TP53 tumor-suppressor protein for ubiquitin-mediated proteolysis. Interacts with BPY2. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 15q11.2
Cellular Component:  cytosol; nucleus; proteasome complex
Molecular Function:  metal ion binding; protein binding; transcription coactivator activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  androgen receptor signaling pathway; brain development; cellular response to brain-derived neurotrophic factor stimulus; negative regulation of dendritic spine morphogenesis; ovarian follicle development; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein ubiquitination; positive regulation of transcription by RNA polymerase II; progesterone receptor signaling pathway; prostate gland growth; protein autoubiquitination; protein K48-linked ubiquitination; proteolysis; regulation of circadian rhythm; regulation of ubiquitin-dependent protein catabolic process; response to cocaine; response to hydrogen peroxide; response to progesterone; rhythmic process; sperm entry; viral process
Disease: Angelman Syndrome
Reference #:  Q05086 (UniProtKB)
Alt. Names/Synonyms: ANCR; AS; CTCL tumor antigen se37-2; E6-AP; E6AP; E6AP ubiquitin-protein ligase; EPVE6AP; FLJ26981; HPVE6A; human papilloma virus E6-associated protein; Human papillomavirus E6-associated protein; Oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY-REN-54; UBE3A; ubiquitin protein ligase E3A; Ubiquitin-protein ligase E3A
Gene Symbols: UBE3A
Molecular weight: 100,688 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB  |  Ensembl Protein