UBE3A E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation. Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation. Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC. Synergizes with WBP2 in enhancing PGR activity. (Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 15q11.2
Cellular Component:  cytosol; nucleus; proteasome complex
Molecular Function:  metal ion binding; protein binding; transcription coactivator activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  androgen receptor signaling pathway; brain development; cellular response to brain-derived neurotrophic factor stimulus; negative regulation of dendritic spine morphogenesis; ovarian follicle development; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein ubiquitination; positive regulation of transcription by RNA polymerase II; progesterone receptor signaling pathway; prostate gland growth; protein autoubiquitination; protein K48-linked ubiquitination; proteolysis; regulation of circadian rhythm; regulation of ubiquitin-dependent protein catabolic process; response to cocaine; response to hydrogen peroxide; response to progesterone; rhythmic process; sperm entry; viral process
Disease: Angelman Syndrome
Reference #:  Q05086 (UniProtKB)
Alt. Names/Synonyms: ANCR; AS; CTCL tumor antigen se37-2; E6-AP; E6AP; E6AP ubiquitin-protein ligase; EPVE6AP; FLJ26981; HECT-type ubiquitin transferase E3A; HPVE6A; human papilloma virus E6-associated protein; Human papillomavirus E6-associated protein; Oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY-REN-54; UBE3A; ubiquitin protein ligase E3A; Ubiquitin-protein ligase E3A
Gene Symbols: UBE3A
Molecular weight: 100,688 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB  |  Ensembl Protein