p15-INK4B a potent inhibitor that interacts strongly with CDK4 and CDK6. Potential effector of TGF-beta induced cell cycle arrest. Heterodimer of CDKN2B with CDK4 or CDK6. Isoform 2 does not interact with CDK4 nor CDK6. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Inhibitor; Protein kinase, regulatory subunit; Tumor suppressor
Chromosomal Location of Human Ortholog: 9p21.3
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  cyclin-dependent protein serine/threonine kinase inhibitor activity; protein binding; protein kinase binding
Biological Process:  cell cycle arrest; cellular response to extracellular stimulus; cellular response to nutrient; cellular senescence; G2/M transition of mitotic cell cycle; megakaryocyte differentiation; mitotic cell cycle checkpoint; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of epithelial cell proliferation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of cyclin-dependent protein serine/threonine kinase activity; spleen development
Reference #:  P42772 (UniProtKB)
Alt. Names/Synonyms: CDK inhibitory protein; CDK4B inhibitor; CDK4I; CDKN2B; CDN2B; Cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinases 4 and 6 binding protein; INK4B; MTS-2; MTS2; Multiple tumor suppressor 2; p14-INK4b; p14_CDK inhibitor; p14_INK4B; P15; p15 CDK inhibitor; p15-INK4b; p15_INK4B; p15INK4B; TP15
Gene Symbols: CDKN2B
Molecular weight: 14,722 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein