Tks5 a scaffolding protein required for podosome formation, degradation of the extracellular matrix, and for invasion in some cancer cells. Other phox proteins are involved in vesicular trafficking, protein sorting and lipid modification. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 19|19 C3
Cellular Component:  cell junction; cell projection; cytoplasm; podosome
Molecular Function:  phosphatidylinositol binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; protease binding; protein binding; superoxide-generating NADPH oxidase activator activity
Biological Process:  osteoclast fusion; reactive oxygen species metabolic process; superoxide metabolic process
Reference #:  O89032 (UniProtKB)
Alt. Names/Synonyms: AI413738; C230050L11; EG329070; Fish; Five SH3 domain-containing protein; five SH3 domains; Gm5098; MGC144076; MGC190848; MGC190948; SH3 and PX domain-containing protein 2A; SH3 and PX domains 2A; SH3 multiple domains 1; SH3 multiple domains protein 1; Sh3md1; Sh3pxd2a; SPD2A
Gene Symbols: Sh3pxd2a
Molecular weight: 124,201 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
Select Structure to View Below

Tks5

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene