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Tks5
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. Belongs to the SH3PXD2 family. Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 10q24.33 |
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Cellular Component:
anchoring junction; cell projection; cytoplasm; cytosol; podosome
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Molecular Function:
phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; protease binding; protein binding; superoxide-generating NADPH oxidase activator activity
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Biological Process:
in utero embryonic development; osteoclast fusion; superoxide anion generation; superoxide metabolic process
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Reference #:
Q5TCZ1
(UniProtKB)
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Alt. Names/Synonyms: Adapter protein TKS5; Adaptor protein TKS5; FISH; Five SH3 domain-containing protein; five SH3 domains; KIAA0418; SH3 and PX domain-containing protein 2A; SH3 and PX domains 2A; SH3 multiple domains 1; SH3 multiple domains protein 1; SH3MD1; SH3PXD2A; SPD2A; Tks5; Tyrosine kinase substrate with five SH3 domains
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Gene Symbols: SH3PXD2A
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Molecular weight:
125,289 Da
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Basal Isoelectric point:
9.01
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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