Tks5 Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. Belongs to the SH3PXD2 family. Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 10q24.33
Cellular Component:  cell junction; cell projection; cytosol; podosome
Molecular Function:  phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; protease binding; protein binding
Biological Process:  extracellular matrix organization; osteoclast fusion; positive regulation of catalytic activity; superoxide metabolic process
Reference #:  Q5TCZ1 (UniProtKB)
Alt. Names/Synonyms: Adapter protein TKS5; Adaptor protein TKS5; FISH; Five SH3 domain-containing protein; five SH3 domains; KIAA0418; SH3 and PX domain-containing protein 2A; SH3 and PX domains 2A; SH3 multiple domains 1; SH3 multiple domains protein 1; SH3MD1; SH3PXD2A; SPD2A; Tks5; Tyrosine kinase substrate with five SH3 domains
Gene Symbols: SH3PXD2A
Molecular weight: 125,289 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Tks5

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene