p16-INK4A iso5 Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nucleolus; Tumor suppressor
Chromosomal Location of Human Ortholog: 9p21.3
Cellular Component:  cytoplasm; cytosol; nucleus; senescence-associated heterochromatin focus
Molecular Function:  cyclin-dependent protein serine/threonine kinase inhibitor activity; NF-kappaB binding; protein binding; protein kinase binding
Biological Process:  cell cycle arrest; cellular senescence; G1/S transition of mitotic cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cell-matrix adhesion; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of NF-kappaB transcription factor activity; negative regulation of phosphorylation; negative regulation of transcription, DNA-templated; positive regulation of cellular senescence; positive regulation of macrophage apoptotic process; positive regulation of smooth muscle cell apoptotic process; Ras protein signal transduction; replicative senescence; senescence-associated heterochromatin focus assembly
Disease: Li-fraumeni Syndrome 1; Melanoma, Cutaneous Malignant, Susceptibility To, 2; Melanoma-astrocytoma Syndrome; Melanoma-pancreatic Cancer Syndrome
Reference #:  Q8N726 (UniProtKB)
Alt. Names/Synonyms: Alternative reading frame; ARF; CD2A2; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; CDKN2A; cell cycle negative regulator beta; CMM2; cyclin dependent kinase inhibitor 2A; cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); Cyclin-dependent kinase inhibitor 2A, isoform 4; cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase inhibitor p16; INK4; INK4a; MLM; MTS-1; MTS1; multiple tumor suppressor 1; p14; p14ARF; p16; p16-INK4; p16-INK4a; p16-INK4A iso5; p16INK4; p16INK4a; p19; p19ARF; TP16; Tumor suppressor ARF
Gene Symbols: CDKN2A
Molecular weight: 13,903 Da
Basal Isoelectric point: 12.41  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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p16-INK4A iso5

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene