AEBP1 May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Transcription factor
Chromosomal Location of Human Ortholog: 7p13
Cellular Component:  cytoplasm; nucleus
Molecular Function:  calmodulin binding; collagen binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; extracellular matrix structural constituent; RNA polymerase II regulatory region sequence-specific DNA binding; zinc ion binding
Biological Process:  negative regulation of transcription by RNA polymerase II; regulation of collagen fibril organization
Disease: Ehlers-danlos Syndrome, Classic-like, 2
Reference #:  Q8IUX7 (UniProtKB)
Alt. Names/Synonyms: ACLP; adipocyte enhancer binding protein 1; Adipocyte enhancer-binding protein 1; AE binding protein 1; AE-binding protein 1; AEBP1; Aortic carboxypeptidase-like protein; FLJ33612
Gene Symbols: AEBP1
Molecular weight: 130,929 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB