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AEBP1
Isoform 1: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellualr matrix. Isoform 2: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Belongs to the peptidase M14 family. Expressed in osteoblast and visceral fat. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide; Transcription factor |
| Chromosomal Location of human Ortholog: 7p13 |
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Cellular Component:
cytoplasm; extracellular space; nucleus
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Molecular Function:
calmodulin binding; collagen binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; extracellular matrix structural constituent; metallocarboxypeptidase activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; zinc ion binding
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Biological Process:
negative regulation of transcription by RNA polymerase II; peptide metabolic process; protein processing; regulation of collagen fibril organization
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Disease: Ehlers-danlos Syndrome, Classic-like, 2
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Reference #:
Q8IUX7
(UniProtKB)
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Alt. Names/Synonyms: ACLP; adipocyte enhancer binding protein 1; Adipocyte enhancer-binding protein 1; AE binding protein 1; AE-binding protein 1; AEBP1; Aortic carboxypeptidase-like protein; FLJ33612
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Gene Symbols: AEBP1
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Molecular weight:
130,929 Da
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Basal Isoelectric point:
5.05
Predict pI for various phosphorylation states
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