RACK7 a DNA damage response (DDR) protein, receptor for activated C-kinase (RACK) protein, and a transcriptional regulator. A bromodomain (BRD)-containing protein that recruits the nucleosome remodeling and histone deacetylation (NuRD) complex to damaged chromatin. Targets DNA damage within actively transcribed regions, repressing transcription, and promoting repair by homologous recombination. A cutaneous T-cell lymphoma-associated antigen that contains a bromodomain and two zinc fingers. Twenty-two alternatively spliced isoforms of the human protein hve been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 2|2 H3
Cellular Component:  cytoplasm; dendritic shaft; dendritic spine; nucleus
Molecular Function:  methylated histone residue binding; protein N-terminus binding
Biological Process:  modulation of excitatory postsynaptic potential; negative regulation of cell migration; positive regulation of filopodium formation
Reference #:  Q80Y82 (UniProtKB)
Alt. Names/Synonyms: 1110013E22Rik; 2010005I16Rik; 3632413B07Rik; AI316811; AL024039; MGC25852; mKIAA1125; Prkcbp1; Protein kinase C binding protein 1; RACK7; zinc finger, MYND-type containing 8; Zmynd8
Gene Symbols: Zmynd8
Molecular weight: 139,193 Da
Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states
Select Structure to View Below

RACK7

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene