Stargazin Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. Brain. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of rat Ortholog: 7q34
Cellular Component:  AMPA glutamate receptor complex; cell surface; cerebellar mossy fiber; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; postsynaptic density membrane; Schaffer collateral - CA1 synapse; somatodendritic compartment; voltage-gated calcium channel complex
Molecular Function:  calcium channel regulator activity; channel regulator activity; ionotropic glutamate receptor binding; protein binding; voltage-gated calcium channel activity
Biological Process:  calcium ion transmembrane transport; eye blink reflex; membrane depolarization; membrane hyperpolarization; nervous system process; neuromuscular junction development; neurotransmitter receptor internalization; neurotransmitter receptor localization to postsynaptic specialization membrane; neurotransmitter receptor transport, postsynaptic endosome to lysosome; positive regulation of AMPA receptor activity; positive regulation of protein localization to basolateral plasma membrane; positive regulation of synaptic transmission, glutamatergic; postsynaptic neurotransmitter receptor diffusion trapping; protein targeting to membrane; regulation of AMPA receptor activity; regulation of membrane potential; regulation of postsynaptic membrane neurotransmitter receptor levels; response to calcium ion; transmission of nerve impulse
Reference #:  Q71RJ2 (UniProtKB)
Alt. Names/Synonyms: Cacng2; calcium channel, voltage-dependent, gamma subunit 2; Ipr328; Stargazin; Voltage-dependent calcium channel gamma-2 subunit
Gene Symbols: Cacng2
Molecular weight: 35,895 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene