FNBP1L Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. Belongs to the FNBP1 family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 3|3 G1
Cellular Component:  cytoplasm; cytoplasmic vesicle; cytoskeleton; membrane; plasma membrane
Molecular Function:  lipid binding
Biological Process:  autophagy; cilium assembly; endocytosis
Reference #:  Q8K012 (UniProtKB)
Alt. Names/Synonyms: 2610318I01Rik; AW548221; FBP1L; Fnbp1l; formin binding protein 1-like; Formin-binding protein 1-like; MGC30506; TOC; Toca-1; Toca1; Transducer of Cdc42-dependent actin assembly protein 1
Gene Symbols: Fnbp1l
Molecular weight: 69,885 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
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FNBP1L

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene