FNBP1L Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. Belongs to the FNBP1 family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1p22.1
Cellular Component:  cell cortex; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; plasma membrane
Molecular Function:  GTPase binding; lipid binding; protein binding
Biological Process:  autophagy; cilium assembly; clathrin-dependent endocytosis; membrane invagination; membrane organization; plasma membrane tubulation; positive regulation of filopodium assembly; vesicle budding from membrane; vesicle organization; vesicle transport along actin filament
Reference #:  Q5T0N5 (UniProtKB)
Alt. Names/Synonyms: C1orf39; FBP1L; FNBP1L; formin binding protein 1-like; Formin-binding protein 1-like; Toca-1; TOCA1; transducer of Cdc42-dependent actin assembly 1; Transducer of Cdc42-dependent actin assembly protein 1
Gene Symbols: FNBP1L
Molecular weight: 70,065 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein