|
PAK6
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 2.7.11.1; Kinase, protein; Nuclear receptor co-regulator; PAKB subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family |
| Chromosomal Location of human Ortholog: 15q15.1 |
|
Cellular Component:
cell junction; cytoplasm; cytosol; fibrillar center; nucleoplasm; postsynaptic density
|
|
Molecular Function:
ATP binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
|
|
Biological Process:
apoptotic process; cytoskeleton organization; intracellular signal transduction; learning; locomotory behavior; memory; neuron projection arborization; neuron projection extension; protein phosphorylation; regulation of DNA-templated transcription; regulation of MAPK cascade
|
|
Reference #:
Q9NQU5
(UniProtKB)
|
|
Alt. Names/Synonyms: p21 (RAC1) activated kinase 6; p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated kinase 6; p21-activated protein kinase 6; PAK-5; PAK-6; PAK5; PAK6; Serine/threonine-protein kinase PAK 6
|
|
Gene Symbols: PAK6
|
|
Molecular weight:
74,869 Da
|
|
Basal Isoelectric point:
9.57
Predict pI for various phosphorylation states
|
