LHX3 Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1. Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 2 A3|2 18.44 cM
Cellular Component:  nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding
Biological Process:  cell differentiation; dorsal/ventral pattern formation; medial motor column neuron differentiation; motor neuron axon guidance; negative regulation of apoptotic process; neuron differentiation; pituitary gland development; placenta development; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; spinal cord association neuron differentiation; spinal cord motor neuron cell fate specification; ventral spinal cord interneuron specification
Reference #:  P50481 (UniProtKB)
Alt. Names/Synonyms: Homeobox protein LIM-3; Homeobox protein P-LIM; Lhx3; LIM homeo box protein 3; LIM homeobox protein 3; Lim-3; LIM/homeobox protein Lhx3; Lim3; mLim; mLim-3; mLIM3; OTTMUSP00000013661; P-LIM; Plim
Gene Symbols: Lhx3
Molecular weight: 44,010 Da
Basal Isoelectric point: 7.87  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene