LHX3 Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1. Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 9q34.3
Cellular Component:  chromatin; nucleus; transcription regulator complex
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription coactivator binding
Biological Process:  animal organ morphogenesis; apoptotic process; inner ear development; lung development; medial motor column neuron differentiation; motor neuron axon guidance; negative regulation of apoptotic process; neuron differentiation; placenta development; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; prolactin secreting cell differentiation; regulation of transcription by RNA polymerase II; somatotropin secreting cell differentiation; spinal cord association neuron differentiation; spinal cord motor neuron cell fate specification; thyroid-stimulating hormone-secreting cell differentiation; ventral spinal cord interneuron specification
Disease: Pituitary Hormone Deficiency, Combined, 3
Reference #:  Q9UBR4 (UniProtKB)
Alt. Names/Synonyms: CPHD3; DKFZp762A2013; LHX3; LIM homeobox 3; LIM homeobox protein 3; LIM/homeobox protein Lhx3; LIM/homeodomain protein LHX3; LIM3; M2-LHX3
Gene Symbols: LHX3
Molecular weight: 43,358 Da
Basal Isoelectric point: 8.47  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein