M6PR Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of mouse Ortholog: 6 F1|6 57.52 cM
Cellular Component:  endosome; Golgi apparatus; late endosome; lysosome; membrane; perinuclear region of cytoplasm; trans-Golgi network
Molecular Function:  protein binding; protein domain specific binding; retromer complex binding
Biological Process:  intracellular protein transport; lysosomal transport; protein targeting to lysosome; secretion of lysosomal enzymes
Reference #:  P24668 (UniProtKB)
Alt. Names/Synonyms: 46 kDa mannose 6-phosphate receptor; 46mpr; Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CD-M; CD-MPR; M6pr; mannose-6-phosphate receptor, cation dependent; Mpr; MPR 46; Mpr46; MPRD; OTTMUSP00000028254; OTTMUSP00000028255
Gene Symbols: M6pr
Molecular weight: 31,172 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein